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Publication

A chiral switch: balancing between equilibrium and non-equilibrium states

Article
Chem. Comm, 2019, in press
Year
2019
Customer
AMOLF
Site
Department
MCS people
Michel Leeman, Richard Kellogg
Publication

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

Article
Organic & Biomolecular Chemistry, 2019, 17, 35-38
Year
2019
Customer
AMOLF
Site
Department
MCS people
Michel Leeman, Richard Kellogg,
Publication

Bivalent Ligands for Protein Degradation in Drug Discovery

Article
Comp. and Struc. Biotech. J., (17), 2019, 160-176
Year
2019
Customer
MercachemSyncom
Site
Department
MCS people
Marcel Scheepstra, Koen Hekking, Luc van Hijfte, Rutger Folmer
Publication

Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors

Article
J. Med. Chem, 2019 (62), 10757-10782
Year
2019
Customer
Goethe University Frankfurt
Site
Department
MCS people
Rob Winkel, Koen Hekking, Jorg Benningshof
Publication

Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2

Article
Bioorganic & Medicinal Chemistry Letters, 2019, (17), 2516-2524
Year
2019
Customer
Eurostar grant, with Proqinase
Site
Department
MCS people
Ruben Leenders, Remco Zijlmans, Bart van Bree, Marc van de Sande, FedericaTrivarellia, Eddy Damen, Anita Wegert, Gerhard Müller
Publication

Drug-target residence time: A misleading concept

Article
Drug Discovery 23, 1, (2018,) 12-16
Year
2018
Customer
Site
Department
MCS people
Rutger folmer
Publication

Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-β-lactams

Article
Bioorg. Med. Chem. 2018, 26, 41-49
Year
2018
Customer
Leiden University Medical Center
Site
Department
MCS people
Joyce van den Heuvel, Rik Megens, Jorg Benningshof
Publication

Structure–Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7

Article
ChemMedChem, 2018, 13, 1405 – 1413
Year
2018
Customer
Institute for Molecules and Materials
Site
Department
MCS people
Eddy Damen, Ruben Leenders, Richard Blaauw
Publication

Synthesis of yellow fluorescent dyes derived from benzoxanthene that can be used in colour converters for remote phosphor LED systems

Article
Dyes and pigments, 2018, 149, 662-668
Year
2018
Customer
Philips
Site
Department
MCS people
Sylvain Hamon, Ton Visser
Publication

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Article
Journal of Medicinal Chemistry, 2018, 61, (9), 3870-3888
Year
2018
Customer
TI Pharma
Site
Department
MCS people
Johan Veerman, Toine van de Bergh

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